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Chang Liu — Dr. Chang Liu's lab at the University of Massachusetts Amherst focuses on innovative technologies for improving HIV detection and prevention. The team is developing a new self-test device that allows individuals to conduct HIV tests using just a drop of blood from their finger. This is designed to enhance early detection of infections and help monitor therapy effectiveness in a user-friendly way, potentially transforming HIV testing into an accessible, at-home process.
Sankaran Thayumanavan — Professor Sankaran Thayumanavan's lab at the University of Massachusetts Amherst focuses on innovative approaches to deliver protein-based therapeutics, which can target hard-to-reach areas inside cells. They are developing advanced nanostructures, such as nanogels, to help these proteins bypass cellular barriers, making them effective in treating diseases caused by specific mutations. The lab's research aims to enhance the efficacy and specificity of these therapies by exploring novel strategies for intracellular delivery and degradation of proteins.
Lila M Gierasch — Dr. Lila Gierasch's lab focuses on understanding how proteins fold correctly within cells, particularly through the action of heat shock proteins like Hsp70. These molecular chaperones play a critical role in maintaining protein health by helping them achieve their functional forms and preventing misfolding that can cause diseases like Alzheimer's and Parkinson's. The lab employs various biochemical techniques to study the mechanisms of protein binding and the effects of mutations on these processes, aiming to find new ways to target these proteins for disease intervention.
Xiaohui Frank Zhang — Dr. Xiaohui Frank Zhang's lab focuses on improving kidney transplantation outcomes through innovative imaging technology. The lab is developing a novel device using Optical Coherence Tomography (OCT) to non-invasively assess kidney viability before transplantation. This research aims to provide real-time, accurate evaluations of donor kidneys, helping minimize complications and improve survival rates for transplant patients.
Paul S Katz — Dr. Paul S Katz's lab at the University of Massachusetts Amherst focuses on understanding how the brain develops by constructing detailed wiring diagrams, called connectomes, of the brain in a mollusk model called Berghia stephanieae. The lab investigates how new neurons are integrated into existing neural circuits and how these connections evolve over time. This research aims to shed light on the fundamental processes of neurogenesis and help us understand neurological diseases related to improper brain development.
Stephen M Rich — Dr. Stephen M. Rich's lab at the University of Massachusetts Amherst focuses on tackling vector-borne diseases, particularly those transmitted by ticks in New England. The lab collaborates with regional universities and aims to control tick populations and reduce Lyme disease cases through applied research, training public health entomologists, and engaging the community. Their work is critical for public health and involves developing strategies and technologies to better manage and prevent tick bites.
Jeanne Ann Hardy — Dr. Jeanne Ann Hardy's lab at the University of Massachusetts Amherst focuses on developing new antiviral therapies for the Chikungunya virus, which causes debilitating joint pain in millions worldwide. They study the viral protease, a critical component for the virus's replication, to design inhibitors targeting both its active site and a newly discovered allosteric site. Their innovative approach combines structural insights with rigorous testing to create effective treatments against this mosquito-borne virus.
Donghyun Kim — Dr. Donghyun Kim's lab at the University of Massachusetts Amherst focuses on creating innovative robotic solutions for individuals with visual impairments. With a commitment to human-centered design, the lab engages closely with the visually impaired community to understand their needs and develop guide-dog robots that enhance mobility and independence. This research aims to bridge gaps in the current systems and provide scalable alternatives to traditional guide dogs, helping to improve the quality of life for people who are blind or have low vision.
Joyita Dutta — Dr. Joyita Dutta's research lab focuses on using wearable technology to discover biomarkers for early detection of Alzheimer's disease. The lab is investigating how changes in sleep patterns, monitored by devices like smartwatches and EEG headbands, can signal the risk of developing Alzheimer's in older adults. By combining data from these wearables with genetic information, the research aims to improve early diagnosis and ultimately contribute to better management of the disease.