University of Massachusetts-Amherst · ChemistryChikungunya Antiviral Research Lab
Jeanne Ann Hardy · Amherst, Massachusetts
Research Focus
Dr. Jeanne Ann Hardy's lab at the University of Massachusetts Amherst focuses on developing new antiviral therapies for the Chikungunya virus, which causes debilitating joint pain in millions worldwide. They study the viral protease, a critical component for the virus's replication, to design inhibitors targeting both its active site and a newly discovered allosteric site. Their innovative approach combines structural insights with rigorous testing to create effective treatments against this mosquito-borne virus.
Chikungunya virusantiviral therapiesviral proteaseallosteric inhibitorsmethyltransferase-like domain
Research Aims
5AIM 01Develop novel inhibitors targeting the Chikungunya virus protease.
AIM 02Explore the role of RNA in enhancing protease activity.
AIM 03Compare the efficacy of active-site versus allosteric inhibitors.
AIM 04Utilize structural insights for inhibitor design and development.
AIM 05Investigate resistance mutations to create durable antivirals.
Skills the Lab Values
NMR spectroscopycompound screeningprotein binding assaysmolecular cloningdirected evolution
Output against the department
Publications95bottom 20% of dept.172nd of 216
this lab
most publishedleast published
Citations3.1kbottom 20% of dept.173rd of 216
this lab
most citedleast cited
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