University of Massachusetts-Amherst · ChemistryBiofilm Breakthrough Lab
Vincent M. Rotello · Amherst, Massachusetts
Research Focus
Dr. Vincent M. Rotello leads a research lab focused on developing innovative treatments for wound infections caused by multidrug-resistant bacteria. The lab combines synthetic chemistry with nanotechnology to create antimicrobial polymers and phage-polymer nanoparticles that can effectively target and eradicate biofilm infections. By integrating machine learning and computational modeling, the lab aims to improve the efficacy and safety of these novel therapies.
antimicrobial polymersphage therapynanoparticleswound biofilm infectionsmultidrug-resistant bacteriahydrogelsbiofilm penetrationmolecular designdrug delivery
Research Aims
3AIM 01Develop antimicrobial polymers to enhance efficacy against multidrug-resistant biofilms.
AIM 02Create phage-polymer nanoparticles for targeted delivery in wound infections.
AIM 03Test polymer-hydrogel systems in preclinical wound biofilm models.
Skills the Lab Values
polymer synthesisnanoparticle formulationhydrogel developmentin vivo testingcell culturemicroscopy techniquesmachine learning applicationsbiofilm model assaysbioluminescence imaging
Output against the department
Publications1,096top 4% of dept.8th of 216
this lab
most publishedleast published
Citations74ktop 2% of dept.5th of 216
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.