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Richard P Mayeux — Dr. Richard P Mayeux's lab at Columbia University focuses on studying blood-based biomarkers for Alzheimer's Disease, particularly in diverse populations. They investigate how these biomarkers can help improve diagnosis and understanding of the disease, using innovative techniques and community-based studies. Their work aims to identify genetic risk factors and how various elements like age, sex, and race impact Alzheimer's diagnosis.
Philip L De Jager — Professor Philip L De Jager's lab focuses on understanding Alzheimer's disease (AD) and its complexities as people age. They use advanced technologies to create detailed maps of the brain's molecular changes and how these changes affect cognition. By studying both genetic factors and brain pathology, the lab aims to uncover new insights into AD, potentially paving the way for improved treatments.
Soojin Park — Dr. Soojin Park's lab at Columbia University Health Sciences focuses on improving the management of patients suffering from acute hydrocephalus and delayed cerebral ischemia, particularly after brain injuries like subarachnoid hemorrhages. The lab leverages machine learning and artificial intelligence to develop predictive models that help identify complications early, aiming to reduce hospital stays and improve patient outcomes. Research utilizes data from patient monitoring to enhance decision-making processes in critical care settings.
Sankar Ghosh — Dr. Sankar Ghosh's lab focuses on understanding the underlying mechanisms of diseases like Inflammatory Bowel Disease and Alzheimer's Disease. By investigating genetic factors and molecular pathways, the lab aims to identify potential therapeutic targets. Through studies on long noncoding RNAs and mitochondrial function, they seek to reveal how these elements contribute to disease susceptibility and progression.
Gerard Karsenty — Dr. Gerard Karsenty's lab at Columbia University studies the relationship between bone health and aging. The research explores how bones not only decline with age but also play an active role in regulating various bodily functions. By understanding these connections, the lab aims to uncover new ways to combat age-related bone loss and improve overall health during aging.
Riccardo Dalla-Favera — Dr. Riccardo Dalla-Favera's lab focuses on understanding diffuse large B cell lymphoma (DLBCL), a common and challenging type of blood cancer. The research team is uncovering genetic mutations within the non-coding regions of DNA that play a critical role in DLBCL. By analyzing super-enhancers—regulatory regions of the genome—they aim to identify new therapeutic targets and improve treatment options for patients who currently have limited options.
Jennifer Jaie Manly — Dr. Jennifer Manly's lab at Columbia University focuses on understanding the reasons behind racial disparities in Alzheimer's disease and related cognitive impairments. The lab studies how social and biological factors influence cognitive health, particularly in middle-aged adults from diverse backgrounds. By examining data from a large group of participants, they aim to identify ways to mitigate risks and improve outcomes for those affected by these disparities.
Wei Gu — Dr. Wei Gu's lab at Columbia University focuses on understanding how the p53 tumor suppressor protein regulates metabolism to inhibit tumor growth. By investigating the metabolic pathways influenced by p53, the lab aims to find new therapeutic targets that can effectively suppress cancer while minimizing damage to healthy tissues. This research is particularly important as it explores unconventional mechanisms of tumor suppression, which may open up new avenues for cancer treatment.
James L. Manley — Dr. James L. Manley's lab at Columbia University focuses on understanding the intricate processes involved in mRNA processing and how these processes impact diseases such as cancer and neurodegenerative disorders. The team investigates how mutations in splicing factors contribute to diseases like acute myeloid leukemia and explores the roles of specific proteins associated with conditions like ALS. Through their research, they aim to uncover the molecular mechanisms behind these changes and their consequences in human health.