Columbia University in the City of New York · NeuroscienceDe Jager Neurobiology Lab
Philip L De Jager · New York, New York
Research Focus
Professor Philip L De Jager's lab focuses on understanding Alzheimer's disease (AD) and its complexities as people age. They use advanced technologies to create detailed maps of the brain's molecular changes and how these changes affect cognition. By studying both genetic factors and brain pathology, the lab aims to uncover new insights into AD, potentially paving the way for improved treatments.
Alzheimer's Diseaseaging3D brain imagingmolecular atlasescellular networksproteinopathiescognitive declinegenetic variationsepigeneticstherapeutic targets
Research Aims
5AIM 01Create 3D molecular atlases of the aging brain to study cognitive decline.
AIM 02Investigate the effects of Alzheimer's proteinopathies on brain architecture.
AIM 03Analyze interactions between genetic variants associated with Alzheimer's disease.
AIM 04Develop a comprehensive dataset linking genetic, molecular, and clinical data.
AIM 05Facilitate collaboration by sharing data and protocols through a knowledge portal.
Skills the Lab Values
3D imaging analysisspatial transcriptomicsindirect immunofluorescence imaging (4i)cell culturemouse modelsmolecular biology techniquesgenetic editing (CRISPR)data curationbioinformaticsstatistical analysis
Output against the department
Publications1,037top 3% of dept.19th of 671
this lab
most publishedleast published
Citations102ktop 2% of dept.14th of 671
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.