Columbia University in the City of New York · BiologyThe RNA Dynamics Lab
James L. Manley · New York, New York
Research Focus
Dr. James L. Manley's lab at Columbia University focuses on understanding the intricate processes involved in mRNA processing and how these processes impact diseases such as cancer and neurodegenerative disorders. The team investigates how mutations in splicing factors contribute to diseases like acute myeloid leukemia and explores the roles of specific proteins associated with conditions like ALS. Through their research, they aim to uncover the molecular mechanisms behind these changes and their consequences in human health.
mRNA processingcancersplicing factorsALSneurodegenerative diseasestranscriptionprotein interactionsdisease mechanismsRNA regulationpolyadenylation
Research Aims
5AIM 01Investigate how mutations in splicing factors affect mRNA processing in cancer.
AIM 02Characterize the interactions between SF3B1 and SUGP1 to understand splicing disruption.
AIM 03Explore the role of RNA binding proteins in ALS and FTD.
AIM 04Determine the function of polyadenylation factor isoforms in antiviral responses.
AIM 05Analyze the translation potential of eRNAs in human embryonic stem cells.
Skills the Lab Values
PCRcell cultureRNA sequencingWestern blotmolecular cloningbioinformaticsimmunoprecipitationfluorescence microscopyprotein purificationdata analysis in R
Output against the department
Publications417top 11% of dept.113th of 1,033
this lab
most publishedleast published
Citations49ktop 6% of dept.58th of 1,033
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.