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Michael S Wolfe — Dr. Michael S. Wolfe's lab at the University of Kansas focuses on understanding the mechanisms of Alzheimer's disease, particularly how a key enzyme called gamma-secretase processes amyloid precursor proteins. The lab investigates both genetic mutations that lead to familial Alzheimer's disease and broader factors that influence neuron degeneration. By exploring these processes, the team aims to discover new treatment strategies that might benefit individuals suffering from Alzheimer's, especially those with the late-onset form of the disease.
Phil Lee — Dr. Phil Lee's lab at the University of Kansas Medical Center focuses on Alzheimer's disease (AD) and the relationship between brain metabolism and disease pathology. The lab aims to develop advanced imaging techniques to create detailed metabolic maps of the brain, which can help identify changes associated with Alzheimer's and potentially guide new treatment strategies. The research contributes to understanding how brain metabolism affects aging and neurological disorders.
Steven Allan Soper — Dr. Steven Allan Soper's lab focuses on developing rapid diagnostic tools for stroke using markers found in blood. By analyzing RNA from extracellular vesicles in blood samples, the lab aims to create a test that can diagnose acute strokes within 31 minutes. This innovative approach hopes to significantly improve timely treatment rates for stroke patients, which are currently very low due to diagnostic limitations.
Michael J Soares — Dr. Michael J. Soares' lab focuses on understanding how certain cells in a developing embryo interact with the mother's uterus to support a successful pregnancy. The lab studies specialized cells called trophoblasts, which are vital for implantation and placental development. By exploring the processes that regulate these cells, the lab aims to uncover the causes of pregnancy complications and identify potential new ways to help manage these issues.
Jianming Qiu — Dr. Jianming Qiu's lab specializes in developing innovative gene editing therapies for cystic fibrosis (CF), a genetic disorder affecting the lungs. The lab focuses on using advanced techniques like CRISPR and rAAV vectors to correct genetic mutations in patients. Their research aims to enhance gene therapy effectiveness, making it a feasible treatment option for all CF patients, regardless of their specific gene mutations.
X. Long Zheng — Dr. X. Long Zheng's lab at the University of Kansas Medical Center studies a rare blood disorder called immune thrombotic thrombocytopenic purpura (iTTP). They focus on understanding how certain autoantibodies disrupt normal blood function and how genetic factors might contribute to this disease. By using models and advanced techniques, the lab aims to uncover new insights that could lead to better treatments for patients suffering from iTTP and similar conditions.
Matthew W Mosconi — Dr. Matthew W. Mosconi's lab focuses on understanding Fragile X-associated tremor/ataxia syndrome (FXTAS), a neurodegenerative disorder that affects motor skills, particularly in older adults. The lab strives to identify biomarkers and mechanisms that characterize disease progression in FXTAS, studying both genetic factors and brain changes over time. By comparing individuals with FXTAS to those without the syndrome, the research aims to provide insights that could lead to better tracking of the disease and potential treatments.
Jeffrey Statland — Dr. Jeffrey Statland's research lab focuses on improving treatments for facioscapulohumeral muscular dystrophy (FSHD), a genetic muscle disorder that primarily affects children and young adults. The lab aims to validate clinical outcome measures and biomarkers that can help in the development of effective therapies. By conducting prospective studies on pediatric FSHD, the lab hopes to enhance the understanding of the disease and accelerate the process of bringing new treatments to patients.
Anthony Sung — Dr. Anthony Sung's lab at the University of Kansas Medical Center focuses on improving the health of patients with hematologic malignancies by addressing their nutritional needs. Through a project called NOURISH, the lab partners with food banks to deliver tailored food assistance directly to patients in a clinical setting, which aims to combat malnutrition associated with cancer treatments. This innovative approach not only enhances patient care but also explores cost-effective solutions for healthcare systems.