University of Kansas · PharmacologyWolfe Lab
Michael S Wolfe · Lawrence, Kansas
Research Focus
Dr. Michael S. Wolfe's lab at the University of Kansas focuses on understanding the mechanisms of Alzheimer's disease, particularly how a key enzyme called gamma-secretase processes amyloid precursor proteins. The lab investigates both genetic mutations that lead to familial Alzheimer's disease and broader factors that influence neuron degeneration. By exploring these processes, the team aims to discover new treatment strategies that might benefit individuals suffering from Alzheimer's, especially those with the late-onset form of the disease.
Alzheimer's Diseasegamma-secretaseneurodegenerationamyloid precursor proteinfamilial Alzheimer's disease
Research Aims
3AIM 01Determine effects of cholesterol, pH changes, and oxidative stress on gamma-secretase complexes.
AIM 02Elucidate effects of stalled enzyme-substrate complexes on mitochondrial function and autophagy in neurons.
AIM 03Test the ability of gamma-secretase modulators to rescue stalled complexes and their consequences.
Skills the Lab Values
biochemistrycell culturetransgenic animal modelsmicroscopycellular biology
Output against the department
Publications297top 26% of dept.122nd of 462
this lab
most publishedleast published
Citations19ktop 20% of dept.92nd of 462
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.