University of Kansas · BiologyTrophoblast Development Lab
Michael J Soares · Lawrence, Kansas
Research Focus
Dr. Michael J. Soares' lab focuses on understanding how certain cells in a developing embryo interact with the mother's uterus to support a successful pregnancy. The lab studies specialized cells called trophoblasts, which are vital for implantation and placental development. By exploring the processes that regulate these cells, the lab aims to uncover the causes of pregnancy complications and identify potential new ways to help manage these issues.
trophoblastplacentationearly pregnancy losscell differentiationuterine interfacespiral artery remodelinginvasive trophoblaststem cellsgenetic regulation
Research Aims
4AIM 01Investigate the regulatory networks controlling trophoblast cell differentiation.
AIM 02Elucidate the mechanisms behind uterine spiral artery remodeling during pregnancy.
AIM 03Explore the role of invasive trophoblast cells in establishing the uterine-placental interface.
AIM 04Identify pathways that may lead to pregnancy complications if disrupted.
Skills the Lab Values
cell culturegenome-wide analysischromatin landscape studiesgene regulatory network characterizationin vivo modeling in ratshuman tissue handlingtranscriptome analysisimmunostainingqPCRWestern blot
Output against the department
Publications292top 20% of dept.202nd of 1,033
this lab
most publishedleast published
Citations12ktop 30% of dept.314th of 1,033
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.