Loading university
Ronald G Crystal — Dr. Ronald G Crystal's lab focuses on understanding and developing innovative treatments for severe health conditions like Alzheimer's disease and early COPD. They explore the genetic factors and biological mechanisms of these diseases, aiming to create effective gene therapies and interventions. Their research has potential implications for improving the lives of patients with genetic predispositions to these conditions.
Costantino Iadecola — Dr. Costantino Iadecola's lab at Weill Medical College focuses on understanding the links between cerebrovascular health and cognitive function, particularly in the context of Alzheimer's disease. The research explores how genetic factors, such as the ApoE4 allele, and environmental factors, like dietary salt intake, contribute to neurovascular dysfunction and cognitive impairment. By using advanced techniques in live animal models, the lab aims to uncover new insights into brain health and develop potential therapeutic strategies for dementia.
Yi Wang — Dr. Yi Wang's lab focuses on developing innovative MRI techniques to improve the diagnosis and treatment of neurological conditions such as stroke and Alzheimer's disease. They use fluid mechanics principles to enhance tissue perfusion imaging and create new methods for mapping oxygen metabolism in the brain. By refining these MRI-based tools, the lab aims to provide more accurate and reliable assessments of brain health, ultimately aiding in patient management and clinical decision-making.
John Blenis — Dr. John Blenis's lab at Weill Medical College focuses on understanding the intricate signaling pathways that regulate cancer cell growth, metabolism, and resistance to therapy. The lab investigates how tumor cells can exploit metabolic processes, like propionate metabolism, to enhance their invasive capabilities and respond to treatment. By delving into mechanisms like mTORC1 signaling and epithelial-to-mesenchymal transition (EMT), the research aims to identify new therapeutic targets and biomarkers to improve cancer intervention.
John P Moore — Dr. John P. Moore's lab focuses on understanding how the immune system can effectively combat HIV-1, the virus that causes AIDS. By studying broadly neutralizing antibodies (bNAbs), the lab aims to improve both vaccine strategies and treatments for HIV-1 infection. The research involves innovative methods to analyze antibody behavior and viral interactions to enhance our knowledge of immunity against HIV-1.
Taha Merghoub — Dr. Taha Merghoub's lab focuses on understanding the complex role of neutrophils in cancer treatment, particularly how they can both help and harm patients undergoing immunotherapy. The research aims to identify how these immune cells can effectively destroy tumors while also preventing severe side effects associated with treatment. By studying neutrophils in various cancer models and in patient samples, the lab seeks to develop more precise and safer cancer therapies that effectively harness the body's immune response against tumors.
Samie R Jaffrey — Dr. Samie Jaffrey's lab at Weill Medical College focuses on understanding how chemical modifications in RNA molecules influence gene expression and cellular behavior, particularly in the context of cancer and neuronal function. The lab employs innovative techniques to map and analyze these modifications, contributing to the emerging field of epitranscriptomics. Through interdisciplinary collaboration and advanced methodologies, the lab seeks to unravel the complex regulatory mechanisms governing RNA and its impact on health and disease.
Sandra Demaria — Dr. Sandra Demaria's lab focuses on understanding how radiation therapy can enhance the immune response against tumors, particularly in the context of cancer immunotherapy. They are investigating how certain immune cells, called dendritic cells, are influenced by radiation and can help improve the effectiveness of treatments that unleash the immune system against cancer. The team aims to unravel the complex interactions between radiation, immune cells, and tumors to find new ways to boost patient responses to therapy.
Jorge Moscat — Dr. Jorge Moscat's lab focuses on understanding the mechanisms of mesenchymal colorectal cancer (CRC), a highly aggressive type of cancer with poor outcomes and limited treatment options. They aim to uncover how cholesterol metabolism contributes to the development of this cancer and how specific proteins can regulate this process. The lab combines mouse models and human data to identify new potential therapies for CRC, which may help overcome its challenges in treatment.