WMCWeill Medical College of Cornell University · Neuroscience
Cerebrovascular and Cognitive Health Lab
Costantino Iadecola · New York, New York
Research Focus
Dr. Costantino Iadecola's lab at Weill Medical College focuses on understanding the links between cerebrovascular health and cognitive function, particularly in the context of Alzheimer's disease. The research explores how genetic factors, such as the ApoE4 allele, and environmental factors, like dietary salt intake, contribute to neurovascular dysfunction and cognitive impairment. By using advanced techniques in live animal models, the lab aims to uncover new insights into brain health and develop potential therapeutic strategies for dementia.
Alzheimer's diseasecognitive impairmentApoE4dietary sodiumneurovascular dysfunction
Research Aims
4AIM 01Investigate the role of ApoE4 in white matter damage and cognitive decline.
AIM 02Elucidate the effects of tau on neurovascular coupling and brain oxygen delivery.
AIM 03Assess the impact of high salt diets on brain vascular health and cognitive function.
AIM 04Identify novel therapeutic targets to mitigate cerebrovascular dysfunction in dementia.
Skills the Lab Values
mouse models3-photon fluorescence imagingmacrophage activation assayscerebral blood flow measurementgene targeting techniques
Output against the department
Publications644top 8% of dept.55th of 671
this lab
most publishedleast published
Citations76ktop 3% of dept.21st of 671
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.