WMCWeill Medical College of Cornell University · Pharmacology
Neutrophil Immunotherapy Lab
Taha Merghoub · New York, New York
Research Focus
Dr. Taha Merghoub's lab focuses on understanding the complex role of neutrophils in cancer treatment, particularly how they can both help and harm patients undergoing immunotherapy. The research aims to identify how these immune cells can effectively destroy tumors while also preventing severe side effects associated with treatment. By studying neutrophils in various cancer models and in patient samples, the lab seeks to develop more precise and safer cancer therapies that effectively harness the body's immune response against tumors.
neutrophilsT cell therapiesimmunotherapyanti-tumor immunityimmune-related adverse events (irAEs)cancer biologymelanomabreast cancerproteomicssingle-cell RNA sequencing
Research Aims
3AIM 01Characterize gene pathways and tumor-derived factors that define functional subsets of anti-tumorigenic neutrophils.
AIM 02Identify mechanisms of tumor cell destruction used by neutrophils during immunotherapies.
AIM 03Uncover the role of neutrophils in the development of immune-related adverse events (irAEs).
Skills the Lab Values
single-cell RNA sequencingproteomicspreclinical animal modelsimmunological assayscell culturegenetic mouse modelsin vitro testingbiomarker analysisflow cytometrydata integration techniques
Output against the department
Publications845top 3% of dept.14th of 462
this lab
most publishedleast published
Citations53ktop 4% of dept.19th of 462
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.