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Markus Grompe — Markus Grompe's lab focuses on innovative methods for delivering gene therapy specifically targeting the liver, which plays a key role in treating inherited and acquired diseases. They explore the potential of using the biliary duct system for more effective gene therapy administration, especially in patients with liver cirrhosis. Their research aims to improve treatment outcomes by minimizing side effects and enhancing the efficiency of gene delivery methods.
David C. Johnson — David C. Johnson's lab focuses on understanding how the human cytomegalovirus (HCMV) enters host cells, particularly epithelial and endothelial cells. Their research aims to identify and characterize specific cell surface proteins that HCMV uses to infect these cells, which is crucial for developing effective vaccines against the virus. With implications for transplant patients and neonates, this work seeks to uncover new strategies for preventing HCMV-related diseases.
Steven A Shea — Dr. Steven A. Shea's lab focuses on understanding how our body's internal clocks, or circadian rhythms, affect heart health and risk for cardiovascular events. The research investigates how these rhythms influence how the heart responds to stress and daily activities, especially in those with conditions like high blood pressure or sleep apnea. By exploring these connections, the lab aims to improve the timing of therapies for cardiovascular diseases, potentially leading to better health outcomes.
David Hoadley Ellison — The lab led by David Hoadley Ellison focuses on understanding the diverse cell types in the kidney, specifically in regions crucial for solute retention. By employing advanced techniques to analyze these cells in health and stress conditions, the research aims to unravel mechanisms that may lead to kidney dysfunction and related diseases. Students in this lab will learn about the unique roles of different kidney cell types and how they respond to dietary changes and drug treatments.
Rosalie C Sears — Dr. Rosalie C. Sears' lab at Oregon Health & Science University focuses on improving early detection methods for pancreatic cancer. The research aims to develop sensitive blood tests and advanced imaging techniques that can identify cancer in its early stages, particularly for high-risk populations. Additionally, the lab is dedicated to addressing community engagement and increasing screening participation among underrepresented groups.
Bonnie J. Nagel — Dr. Bonnie J. Nagel's lab focuses on understanding how children's cognitive and emotional development is affected by various factors, including mental health issues and environmental influences. The lab uses advanced mathematical and computational approaches to refine diagnostic tools that help clinicians identify and predict child psychopathology. By analyzing large datasets, including electronic medical records and brain imaging data, the lab aims to improve the diagnosis and treatment of mental health conditions in children.
Leslie Hammer — Dr. Leslie Hammer's lab focuses on understanding the complexities of the workplace and how it affects worker health and wellbeing. The lab uses research to explore innovative solutions to enhance the health of workers and their families. Projects incorporate interdisciplinary approaches to improve mental health, support work-life balance, and promote healthier work environments.
Andrew Adey — Dr. Andrew Adey's lab at Oregon Health & Science University studies how DNA methylation affects the development of mammalian cells. By using advanced techniques, they create detailed maps of how this modification changes during the growth of embryos. Their research aims to understand the roles of DNA methylation in cell fate decisions and connections to developmental diseases, making their findings important for both biology research and medical applications.
Melissa H. Wong — Dr. Melissa H. Wong's lab focuses on understanding how certain cancer cells spread from primary tumors to other parts of the body, which is a major challenge in treating cancer. They study a specific type of cancer cell, known as circulating hybrid cells, that may play a critical role in metastasis. Through advanced analyses and techniques, the lab aims to uncover the biological mechanisms that allow these cells to disseminate, which could lead to improved treatments for patients with colorectal cancer and other metastatic diseases.