Oregon Health & Science University · GeneticsGrompe Lab
Markus Grompe · Portland, Oregon
Research Focus
Markus Grompe's lab focuses on innovative methods for delivering gene therapy specifically targeting the liver, which plays a key role in treating inherited and acquired diseases. They explore the potential of using the biliary duct system for more effective gene therapy administration, especially in patients with liver cirrhosis. Their research aims to improve treatment outcomes by minimizing side effects and enhancing the efficiency of gene delivery methods.
gene therapyliver cirrhosisbiliary systemretroviral vectorsHepatocyte transduction
Research Aims
3AIM 01Explore the efficacy of intraductal gene therapy to improve biodistribution of therapeutic agents.
AIM 02Evaluate the reduction of systemic side effects through ductal administration of gene therapy agents.
AIM 03Test the effectiveness of gene therapy in cirrhotic liver conditions.
Skills the Lab Values
gene therapy techniquesintraductal injectionrat modelsRNA nanoparticle methodsrecombinant adeno-associated virus (rAAV) production
Output against the department
Publications402top 17% of dept.44th of 259
this lab
most publishedleast published
Citations41ktop 15% of dept.39th of 259
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.