Oregon Health & Science University · Microbiology & ImmunologyThe Viral Entry Lab
David C. Johnson · Portland, Oregon
Research Focus
David C. Johnson's lab focuses on understanding how the human cytomegalovirus (HCMV) enters host cells, particularly epithelial and endothelial cells. Their research aims to identify and characterize specific cell surface proteins that HCMV uses to infect these cells, which is crucial for developing effective vaccines against the virus. With implications for transplant patients and neonates, this work seeks to uncover new strategies for preventing HCMV-related diseases.
HCMVvirus entryepithelial cellsendothelial cellsvaccine developmentcell receptorsviral proteinsimmunology
Research Aims
5AIM 01Characterize new receptors that HCMV uses to enter epithelial and endothelial cells.
AIM 02Identify and analyze cell surface proteins that bind to HCMV glycoproteins.
AIM 03Investigate the role of identified proteins in facilitating or blocking HCMV entry.
AIM 04Assess the effectiveness of soluble forms of receptor proteins in inhibiting HCMV entry.
AIM 05Develop improved models for studying HCMV entry pathways and interactions.
Skills the Lab Values
mass spectrometrycell cultureantibody characterization3D imaginglive cell imagingPCRsiRNA silencingviral recombinantsprotein purificationinfectious biochemistry
Output against the department
Publications100bottom 35% of dept.313th of 486
this lab
most publishedleast published
Citations29ktop 11% of dept.52nd of 486
this lab
most citedleast cited
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