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Qi Zhou — Dr. Qi Zhou's lab focuses on improving treatments for serious lung infections caused by multidrug-resistant bacteria, known as 'superbugs.' They are developing more effective ways to deliver antibiotics directly to the lungs using innovative aerosol systems, while minimizing side effects and preventing bacteria from becoming resistant. Their work combines advanced technologies like imaging and machine learning with pharmacological research to enhance patient outcomes in pulmonary medicine.
Arun K Ghosh — Dr. Arun Ghosh's lab at Purdue University focuses on developing new treatments for HIV/AIDS, particularly through the design and synthesis of innovative protease inhibitors. These inhibitors aim to overcome challenges posed by drug-resistant strains of the virus and improve treatment for patients experiencing complications such as neurocognitive disorders. The lab employs advanced techniques in chemistry and biology to create more effective antiviral agents that are essential for long-term HIV management.
Danzhou Yang — Dr. Danzhou Yang's lab at Purdue University focuses on developing innovative therapies for cancer and inflammatory diseases. The lab investigates the regulation of gene expression, specifically targeting a unique structure in DNA known as a G-quadruplex to suppress the overexpression of a protein called PDGFR-beta, which is implicated in various diseases. By designing and synthesizing small molecular compounds that interact with this structure, the lab aims to create more effective treatments for conditions where PDGFR-beta is a key player.
Yoon Yeo — Dr. Yoon Yeo's lab focuses on developing innovative drug delivery systems to treat eye diseases that cause blindness. They are particularly interested in repurposing the old antifungal drug griseofulvin to create long-acting formulations that can be injected into the eye for treating conditions like age-related macular degeneration. By using new polymer-based delivery methods, the lab aims to improve patient outcomes and convenience while reducing the cost of treatment.
Chi Hwan Lee — Dr. Chi Hwan Lee's research lab at Purdue University is focused on developing innovative smart soft contact lenses designed to monitor intraocular pressure continuously, particularly for glaucoma patients. These contact lenses aim to be comfortable and safe for long-term wear, allowing more accurate tracking of eye pressure to prevent vision loss. The lab combines biomedical engineering principles with advanced material science to create a new generation of ocular devices that could also benefit patients with other eye diseases.
Robert Virgil Stahelin — Robert Stahelin's lab at Purdue University focuses on studying deadly viruses like Ebola, Marburg, and SARS-CoV-2. They investigate how these viruses assemble and spread within human cells, aiming to discover new drug targets for treatment. The lab combines computational methods with experimental techniques to understand the viral proteins and their interactions, which is crucial for combating these significant public health threats.
Deborah W Knapp — Dr. Deborah W. Knapp's lab at Purdue University focuses on improving cancer treatment through innovative research on immune cell responses in both dogs and humans with invasive urinary bladder cancer. By studying naturally-occurring bladder cancer in dogs, the lab aims to advance immunotherapy techniques that can enhance outcomes in human patients. This research not only contributes to better therapy options for bladder cancer but also aims to harness the canine model to explore solutions for other types of cancer.
Meng Cui — Dr. Meng Cui's lab focuses on advancing imaging technologies for neuroscience, specifically through the development of a Light Pipe Microscope (LPM) designed for high-resolution imaging of the mammalian brain. The lab's work aims to enhance our understanding of neural circuits by enabling the observation of brain activity over large areas at a cellular level. By combining engineering innovations and neuroscience, they strive to provide low-cost, high-quality imaging solutions that can be broadly adopted to study brain function and cognition.
Jianing Li — Dr. Jianing Li's lab at Purdue University focuses on developing innovative peptide-based therapies for Alzheimer's Disease (AD) and related dementias (ADRD). By using advanced generative artificial intelligence (AI), the lab aims to design more effective and safer peptide drugs that can better target the causes of these diseases. The research not only seeks to improve drug development processes but also strives to make peptide therapeutics more accessible to researchers and healthcare providers.