Purdue University-Main Campus · PharmacologyStahelin Lab
Robert Virgil Stahelin · West Lafayette, Indiana
Research Focus
Robert Stahelin's lab at Purdue University focuses on studying deadly viruses like Ebola, Marburg, and SARS-CoV-2. They investigate how these viruses assemble and spread within human cells, aiming to discover new drug targets for treatment. The lab combines computational methods with experimental techniques to understand the viral proteins and their interactions, which is crucial for combating these significant public health threats.
EbolaSARS-CoV-2viral assemblyprotein interactionsfilovirusesdrug targetingmolecular dynamicsbiophysicscomputer modeling
Research Aims
5AIM 01Investigate how the VP40 protein of filoviruses forms different oligomeric structures during the viral life cycle.
AIM 02Understand the dynamics of SARS-CoV-2 assembly and determine the role of lipids in viral budding.
AIM 03Study the effects of mutations in VP40 on its conformation and function.
AIM 04Identify novel drug targets by understanding protein-protein interactions in viral assembly.
AIM 05Elucidate the mechanisms of SARS-CoV-2 M and N protein interactions with host lipids.
Skills the Lab Values
molecular dynamics simulationsprotein expression and purificationcell culture techniquesbiophysical methodsultracentrifugationsite-directed mutagenesishydrogen-deuterium exchangestructural biologylipid-protein interaction analysis
Output against the department
Publications271top 29% of dept.134th of 462
this lab
most publishedleast published
Citations9.2ktop 42% of dept.192nd of 462
this lab
most citedleast cited
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