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Chhabi K Govind — Dr. Chhabi K Govind's lab at Oakland University focuses on understanding how cells recover from stress by studying the process of autophagy, which helps cells recycle and degrade components when faced with starvation or other stresses. They use the yeast Saccharomyces cerevisiae as a model organism to explore the role of chromatin structure and specific protein complexes in this recovery process. Their research aims to uncover important mechanisms that maintain cell function and survival during challenging conditions, with implications for health and disease.
Shailesh Lal — Dr. Shailesh Lal's research focuses on understanding a protein called RBM48, which plays a crucial role in the splicing of certain RNA segments called U12 introns. These introns are important for normal cell growth and differentiation, especially in blood cells. By investigating how RBM48 affects the splicing process and the various forms this protein can take, the lab aims to uncover mechanisms that may lead to new treatments for diseases such as leukemia and other conditions linked to splicing errors.
Adam Avery — Dr. Adam Avery's lab at Oakland University focuses on understanding the molecular and cellular mechanisms behind spinocerebellar ataxia type 5 (SCA5), a neurodegenerative disease that affects movement. The lab investigates how mutations in the spectrin protein disrupt the structure and function of dendritic cells, which play a crucial role in neuron signaling. By using Drosophila (fruit fly) models, they aim to elucidate how these mutations lead to impaired neuronal development and explore potential therapeutic approaches.