Oakland University · BiologyLal Lab
Shailesh Lal · Rochester Hills, Michigan
Research Focus
Dr. Shailesh Lal's research focuses on understanding a protein called RBM48, which plays a crucial role in the splicing of certain RNA segments called U12 introns. These introns are important for normal cell growth and differentiation, especially in blood cells. By investigating how RBM48 affects the splicing process and the various forms this protein can take, the lab aims to uncover mechanisms that may lead to new treatments for diseases such as leukemia and other conditions linked to splicing errors.
RNA SplicingHematopoietic Stem CellsCell DifferentiationAcute Myeloid LeukemiaAlternative SplicingGene ExpressionProtein-Protein InteractionsTranscript IsoformsBioinformatics
Research Aims
4AIM 01Investigate the role of RBM48 transcript isoforms in U12 splicing using genetic assays in K562 leukemia cells.
AIM 02Determine the impact of RBM48 on differentiation and self-renewal in hematopoietic stem cells.
AIM 03Elucidate the mechanisms of U12 splicing pathways related to cellular functions and potential disease outcomes.
AIM 04Identify genes and downstream processes regulated by RBM48 in relation to cellular differentiation.
Skills the Lab Values
mRNA sequencingCRISPR/Cas technologycell culturegenetic assaysphenotypic analysisin vitro assaysRNA-Protein Interaction studiesbioinformatics toolsprotein characterization
Output against the department
Publications19bottom 2% of dept.1,009th of 1,033
this lab
most publishedleast published
Citations770bottom 3% of dept.998th of 1,033
this lab
most citedleast cited
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