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Peter L Jones — Dr. Peter L. Jones leads a research lab at the University of Nevada Reno focused on developing innovative therapies for Facioscapulohumeral muscular dystrophy (FSHD) using CRISPR technology. Their work aims to repress the harmful gene DUX4 in muscle cells to alleviate symptoms of this genetic disorder. The lab's efforts include the design of advanced delivery systems for CRISPR components in muscle tissue and testing these in mouse models to establish effective treatment strategies.
Albert Louis Gonzales — Dr. Albert Gonzales' lab at the University of Nevada Reno focuses on understanding how certain brain cells, called pericytes, regulate blood flow in tiny blood vessels called capillaries, and how this process is affected in Alzheimer's disease. The research explores how amyloid-beta proteins disrupt the normal functions of pericytes, which could lead to cognitive decline in aging individuals. By studying these mechanisms, the lab aims to identify potential therapeutic strategies for improving brain health and preventing neurodegeneration associated with Alzheimer's and other vascular diseases.
Sal Baker — Dr. Sal Baker's lab at the University of Nevada Reno studies how specific cells in the colon, called interstitial cells of Cajal (ICC), help control gut movement. They are exploring how these cells interact with smooth muscle and nerves to regulate contractions in the intestines, which is important for understanding disorders like constipation. The goal is to uncover new regulatory mechanisms that could lead to better treatments for gastrointestinal motility issues.
Monika Gulia-Nuss — Dr. Monika Gulia-Nuss's research focuses on understanding the biology of ticks and the pathogens they transmit, such as those causing Lyme disease. The lab is developing advanced genetic techniques, particularly using CRISPR/Cas9, to create genetically modified ticks that can help scientists study how ticks transmit diseases. This work aims to improve tick control strategies and enhance our knowledge of tick biology at the molecular level, ultimately contributing to public health and agricultural advancement.
Lai Wen — Dr. Lai Wen's lab focuses on understanding how certain proteins regulate the adhesion of immune cells, specifically neutrophils, to blood vessel walls during inflammation. This research is crucial for tackling cardiovascular diseases, as inflammation plays a major role in heart-related issues. By exploring the interactions between proteins like kindlin-3 and talin-1, the lab aims to uncover new mechanisms that could lead to innovative therapies to reduce tissue damage during inflammatory responses.