University of Nevada-Reno · PharmacologyFSHD Gene Therapy Lab
Peter L Jones · Reno, Nevada
Research Focus
Dr. Peter L. Jones leads a research lab at the University of Nevada Reno focused on developing innovative therapies for Facioscapulohumeral muscular dystrophy (FSHD) using CRISPR technology. Their work aims to repress the harmful gene DUX4 in muscle cells to alleviate symptoms of this genetic disorder. The lab's efforts include the design of advanced delivery systems for CRISPR components in muscle tissue and testing these in mouse models to establish effective treatment strategies.
CRISPRFSHDmuscular dystrophygene therapyepigenetic regulation
Research Aims
4AIM 01Develop CRISPR-based therapies to target DUX4 gene expression.
AIM 02Evaluate the efficacy of CRISPR inhibition in muscle cells.
AIM 03Test new delivery systems for CRISPR components in vivo.
AIM 04Assess the long-term effects of gene repression in mouse models.
Skills the Lab Values
CRISPR/Cas9gene delivery systemsin vivo modelscell culturemolecular cloning
Output against the department
Publications220top 38% of dept.173rd of 462
this lab
most publishedleast published
Citations17ktop 23% of dept.104th of 462
this lab
most citedleast cited
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