Loading university
Patrick F Sullivan — Dr. Patrick F. Sullivan's lab at the University of North Carolina focuses on understanding the genetic basis of severe mental illnesses like schizophrenia, bipolar disorder, and major depressive disorder. The lab partners with various global institutions to analyze genetic data from patients with these disorders, aiming to uncover specific genetic variations that could lead to new treatments. Through large-scale genomic sequencing and analysis, the lab seeks to increase diversity in genetic research and improve mental health therapies.
Michael Isaiah Love — The Love Lab focuses on developing innovative computational tools for analyzing long-read RNA sequencing data. Their work aims to create user-friendly pipelines that enhance the accuracy and interpretability of RNA sequencing results, making it easier for researchers to study gene expression and its implications in human health and disease. They also provide workshops and tutorials to help biologists and analysts use these tools effectively.
Bryan L. Roth — Dr. Bryan L. Roth's lab focuses on understanding how psychoactive drugs, like LSD, interact with specific receptors in the brain that are crucial for treating mental disorders. They use advanced techniques to study the structures of serotonin and Mas-related receptors to uncover how these drugs work at a molecular level. This research aims to improve drug design for conditions such as schizophrenia and chronic pain, leading to safer and more effective treatments.
Karen L. Mohlke — Dr. Mohlke's lab focuses on understanding the genetic underpinnings of type 2 diabetes (T2D) and related metabolic traits. By conducting extensive genetic analysis, they aim to identify the specific genes and variants that contribute to these conditions, particularly their effects at the cellular level in tissues such as the liver and adipose tissue. This research holds great potential for uncovering new therapeutic targets and improving disease prediction and treatment.
Yun Li — Dr. Yun Li's lab at the University of North Carolina Chapel Hill focuses on understanding the genetic mechanisms underlying Alzheimer's disease, which affects millions of elderly individuals. By using advanced computational methods to analyze a variety of genomic data, the lab aims to uncover how certain genetic variants contribute to the disease. They validate their hypotheses by conducting experiments on induced pluripotent stem cell (iPSC)-derived neural cells and brain organoids, leveraging innovative techniques like CRISPR to explore potential therapeutic targets.
Jeremy N Rich — Dr. Jeremy N. Rich's lab focuses on understanding and treating glioblastoma, a highly aggressive brain cancer. The lab investigates how the metabolism of tumor cells affects their growth and survival, exploring the role of dietary interventions and aging in tumor development. Researchers use cutting-edge techniques to analyze the unique cellular behaviors within glioblastoma and aim to develop novel therapeutic strategies based on their findings.
Aziz Sancar — Dr. Aziz Sancar's research lab at UNC Chapel Hill focuses on understanding how DNA damage and repair processes are influenced by the circadian clock — the body’s internal clock that regulates biological rhythms. The lab employs innovative techniques to map DNA damage and repair at a single-nucleotide level, aiming to improve cancer treatment and prevention by linking these mechanisms to health outcomes. By exploring the relationships between DNA repair, environmental carcinogens, and chronotherapy, the lab contributes significantly to our understanding of cancer biology and personalized medicine.
Li Wang — Dr. Li Wang's lab at UNC Chapel Hill focuses on developing advanced computational tools for analyzing brain imaging data, specifically to study early brain development in infants at risk of autism. The lab's goal is to create methods that can accurately segment and identify brain structures from MRI scans, potentially leading to earlier diagnosis and intervention for autism. By leveraging large-scale neuroimaging datasets, their research seeks to improve our understanding of autism development and create resources for the scientific community.
Gianpietro Dotti — Dr. Gianpietro Dotti's lab at UNC Chapel Hill focuses on developing innovative therapies for ovarian cancer using modified immune cells. The research explores using CAR-T cells that target a specific protein called B7-H3 found on cancer cells. By reprogramming the tumor microenvironment and enhancing the immune response against solid tumors, the lab aims to improve treatment outcomes for patients with ovarian cancer.