University of North Carolina at Chapel Hill · Microbiology & ImmunologyDotti Lab
Gianpietro Dotti · Chapel Hill, North Carolina
Research Focus
Dr. Gianpietro Dotti's lab at UNC Chapel Hill focuses on developing innovative therapies for ovarian cancer using modified immune cells. The research explores using CAR-T cells that target a specific protein called B7-H3 found on cancer cells. By reprogramming the tumor microenvironment and enhancing the immune response against solid tumors, the lab aims to improve treatment outcomes for patients with ovarian cancer.
B7-H3CAR-T therapyovarian cancertumor microenvironmentimmunotherapy
Research Aims
3AIM 01Conduct a Phase I clinical study to assess the safety and effectiveness of B7-H3 CAR-T cells in ovarian cancer patients.
AIM 02Analyze tumor biopsies and ascites to evaluate immune responses and antigen loss during treatment.
AIM 03Reprogram tumor-associated macrophages to reduce their immunosuppressive effects and boost CAR-T therapy success.
Skills the Lab Values
cell cultureCAR-T cell developmentimmunological analysisxenogeneic tumor modelspreclinical studiesclinical trial designbiopsy techniquesflow cytometrysmall molecule inhibitors
Output against the department
Publications700top 3% of dept.16th of 486
this lab
most publishedleast published
Citations39ktop 6% of dept.29th of 486
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.