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Nathan R Tucker — Dr. Nathan R. Tucker's lab focuses on understanding how genetic variations contribute to cardiac arrhythmias, which are irregular heartbeats that can be life-threatening. His research aims to link these genetic variations to their biological mechanisms, potentially leading to new treatments. By using advanced techniques like CRISPR and single nucleus RNA sequencing, the lab investigates the genetic and molecular underpinnings of arrhythmias in heart tissue samples, paving the way for innovative therapeutic approaches.
Adam T Waickman — Dr. Adam T. Waickman's lab focuses on understanding how dengue virus infection interacts with the immune system, particularly through a mechanism called B-cell receptor dependent enhancement (BDE). They investigate why some individuals experience severe symptoms while others remain asymptomatic after infection. Their research aims to reveal how B cells, typically involved in immune protection, can also contribute to the risk of severe dengue outcomes.
Stewart N Loh — Dr. Stewart Loh's lab at Upstate Medical University focuses on understanding systemic amyloidosis, a serious condition caused by misfolded proteins accumulating in various organs like the kidneys and heart. The lab uses innovative microfluidic devices that mimic kidney blood flow to study how shear stress affects protein misfolding and aggregation. The ultimate goal is to create early diagnostic tests using biosensors that can detect these protein aggregates in patients' blood and urine.
Mira Krendel — Dr. Mira Krendel's lab at Upstate Medical University focuses on understanding how the protein myosin 1e affects kidney health, particularly in a type of cell called podocytes. By studying how mutations in this protein lead to kidney disease, the lab aims to develop potential strategies for protecting kidney functions and treating chronic kidney conditions. Overall, the research contributes to our understanding of kidney filtration and health.
Eain A Murphy — Eain Murphy's lab at Upstate Medical University focuses on understanding the link between neurotropic viral infections and Alzheimer's Disease. The research explores how infections by certain herpesviruses might influence the progression of the disease by altering key proteins involved in neurodegeneration. Using advanced 3D brain models, the lab aims to shed light on the biological mechanisms that could lead to new therapeutic strategies for Alzheimer's Disease.