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Jing Tang — Dr. Jing Tang's lab is focused on enhancing diagnostic techniques for coronary artery disease using advanced imaging methods. By integrating machine learning with 4D imaging, the lab aims to improve the accuracy and reliability of myocardial perfusion assessments, which can lead to better patient outcomes in heart disease treatment. The research explores new methodologies that could significantly increase the effectiveness of non-invasive cardiac evaluations.
W Sean Davidson — Dr. W Sean Davidson's lab at the University of Cincinnati focuses on understanding high-density lipoproteins (HDLs), often referred to as 'good cholesterol.' The lab aims to explore how different HDL forms function in protecting against heart disease and diabetes. Through a combination of laboratory experiments and computational modeling, the team investigates the molecular mechanisms of cholesterol transport and the role of specific HDL particles in cardiovascular health.
Maria F Czyzyk-Krzeska — Dr. Maria Czyzyk-Krzeska's lab focuses on understanding the role of copper metabolism in clear cell renal cell carcinoma (ccRCC), a common and aggressive type of kidney cancer. By investigating how copper accumulation affects tumor growth and metabolism, the lab aims to identify new therapeutic strategies and biomarkers to improve treatment outcomes for patients. Their research combines cell line models and patient-derived tumor grafts to uncover critical mechanisms in cancer progression.
Yigang Wang — Dr. Yigang Wang's lab focuses on understanding heart failure, a serious condition affecting millions globally. They explore how specific molecules, called miRNAs, impact heart cells and contribute to heart disease. By studying the mechanisms behind these processes, the lab aims to develop innovative therapies to mitigate heart failure and improve patient outcomes.
Eric S Wohleb — Dr. Eric S Wohleb's lab at the University of Cincinnati investigates how chronic stress impacts the brain, particularly focusing on how stress causes changes in neurons that can lead to mental health disorders like PTSD and depression. The research looks at DNA damage in stressed neurons and how it alters gene activity and neuron structure. By understanding these processes, the lab aims to find new ways to treat stress-related cognitive issues.
Sarah W Whitton — Dr. Sarah W. Whitton's lab focuses on understanding the mental health challenges faced by young sexual minority women, who experience particularly high rates of anxiety, depression, and suicidality. Through a comprehensive longitudinal study, the research aims to identify risk and protective factors influencing mental health outcomes in this group, examining how different mechanisms—biological, psychological, and social—interact with stress related to minority status. The ultimate goal is to leverage these insights to develop effective, culturally sensitive interventions to improve mental health care for sexual minority women.
Chen Gao — Dr. Chen Gao's lab focuses on understanding how the degradation of RNA molecules influences the development of heart diseases, particularly heart hypertrophy. By studying the mechanisms of mRNA stability and degradation in heart cells, the lab aims to uncover new potential targets for treating cardiovascular diseases. Their research combines advanced sequencing technologies with mouse models to explore gene regulation in response to stress and other physiological changes.
Konstantinos Drosatos — Dr. Konstantinos Drosatos' lab at the University of Cincinnati focuses on understanding how diabetes affects heart function, particularly through a protein called GLUT1 that helps transport glucose into heart cells. The lab aims to uncover the mechanisms that lead to heart failure in diabetic patients and explore potential therapies to prevent this condition. Their research could lead to new treatments that improve heart health for individuals suffering from diabetes.
Thomas B Thompson — Dr. Thomas B Thompson's lab at the University of Cincinnati focuses on understanding the TGF-beta family of signaling molecules and how they regulate critical biological processes such as fetal development and adult health. Using cutting-edge techniques from structural biology, biophysics, and computational methods, the lab aims to uncover the details of how these molecules interact and function, which is crucial for developing new therapies for diseases like cancer and cardiovascular issues.