UCUniversity of Cincinnati-Main Campus · Biology
Copper Metabolism in Renal Cancer Lab
Maria F Czyzyk-Krzeska · Cincinnati, Ohio
Research Focus
Dr. Maria Czyzyk-Krzeska's lab focuses on understanding the role of copper metabolism in clear cell renal cell carcinoma (ccRCC), a common and aggressive type of kidney cancer. By investigating how copper accumulation affects tumor growth and metabolism, the lab aims to identify new therapeutic strategies and biomarkers to improve treatment outcomes for patients. Their research combines cell line models and patient-derived tumor grafts to uncover critical mechanisms in cancer progression.
renal cancercopper metabolismtumor growthclear cell carcinomamitochondrial function
Research Aims
3AIM 01Investigate the role of macropinocytosis in copper uptake by renal cancer cells.
AIM 02Understand the regulation of electron transport chain activity by copper levels.
AIM 03Explore the therapeutic implications of copper-dependent vulnerabilities in cancer cells.
Skills the Lab Values
cell culturexenograft modelsRNA sequencingbiochemical assaysflow cytometry
Output against the department
Publications152top 44% of dept.458th of 1,033
this lab
most publishedleast published
Citations10ktop 36% of dept.369th of 1,033
this lab
most citedleast cited
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