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Jun Liu — Jun Liu's lab at Cornell University studies the bone morphogenetic protein (BMP) signaling pathway, which is crucial for proper development and function in organisms. Using the model organism C. elegans, the lab investigates how various proteins and genetic factors regulate BMP signaling and its implications for diseases such as cancer and cardiovascular conditions. Their research aims to uncover the mechanisms behind BMP regulation, which could lead to new therapeutic strategies for disorders related to faulty BMP signaling.
Shaoyi Jiang — Dr. Shaoyi Jiang's lab at Cornell University focuses on understanding how lipid nanoparticles (LNPs) interact with the immune system. By studying the immunogenicity of these nanoparticles, the lab aims to identify which components of LNPs cause adverse immune responses, particularly in the context of vaccine development. Their research seeks to improve the safety and effectiveness of LNPs used in vaccines and therapeutics.
Cedric Feschotte — Dr. Cedric Feschotte's lab at Cornell University studies transposable elements (TEs), which are DNA sequences that can change their position within the genome. These elements are critical for understanding evolution and genetic variation, as they can influence gene expression and contribute to cellular functions. By examining the role of young TEs in human and zebrafish development, the lab aims to uncover their significance in processes like embryonic growth and pregnancy, potentially leading to new insights into diseases such as neurodevelopmental disorders and complications during pregnancy.
John D Helmann — Dr. John D. Helmann's lab at Cornell University studies how bacteria, specifically Bacillus subtilis, respond to stress from both nutrients and antibiotics. They investigate how bacteria manage essential metal ions in the presence of immune responses and how they develop resistance to antibiotics. Their findings contribute to our understanding of bacterial behavior in health and disease, which can help in developing better treatments against pathogenic bacteria.
Chris Xu — Chris Xu's lab at Cornell University focuses on developing innovative imaging techniques to capture high-resolution images of living tissues, particularly in neuroscience. The lab aims to overcome current limitations in optical imaging technologies, enabling researchers to visualize brain structures and functions deeply and rapidly. This research not only enhances our understanding of neural systems but also contributes to advances in various biomedical fields.
B Franklin Pugh — Dr. B Franklin Pugh's lab at Cornell University investigates how genes are regulated in yeast and humans. By starting with the simpler yeast model, they aim to understand the fundamental mechanisms of gene regulation that apply across all eukaryotic life. Their research focuses on mapping the intricate interactions between proteins and DNA, which can lead to improved diagnostics and therapies for diseases in humans.
Chris B Schaffer — Dr. Chris B. Schaffer's lab at Cornell University focuses on understanding how blood flow in the brain affects cognitive functions related to Alzheimer's Disease (AD) and other related dementias. The research investigates how improving blood circulation can enhance memory and correct neural activity imbalances in mouse models. This work aims to uncover mechanisms that could potentially lead to new therapies for cognitive symptoms in AD.
Brian R Crane — The Crane lab at Cornell University focuses on understanding how light and chemical signals influence the behavior of cells, particularly in bacteria and fruit flies. They study key systems that allow cells to move toward certain stimuli, a process crucial for bacteria to cause disease, and also investigate the molecular mechanisms that regulate biological clocks in organisms. By using advanced techniques in biochemistry and structural biology, the lab aims to contribute to our knowledge of diseases that arise when these systems malfunction.
Mandy J Mcgeachy — Dr. Mandy Mcgeachy's lab at Cornell University focuses on understanding how specific immune cells called Th17 cells can either protect the body from infections or contribute to autoimmune diseases like multiple sclerosis. The lab studies molecular mechanisms that influence Th17 cell behavior, especially a process called post-transcriptional regulation, which affects how these cells express key proteins involved in inflammation. By uncovering these pathways, the lab hopes to identify new therapeutic targets that can help manage autoimmune conditions.