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Peter L. Anderson — Dr. Peter L. Anderson's lab focuses on improving HIV treatment methods through the development of personalized medication dosing strategies. The research aims to validate a system that allows patients to collect their own samples and test drug levels easily at home. This work is critical for optimizing long-acting antiretroviral therapies, ensuring that each patient's treatment is tailored to their unique needs, ultimately enhancing health outcomes for individuals living with HIV.
James V Degregori — Dr. James V Degregori's research lab at the University of Colorado Denver focuses on how respiratory viral infections, such as influenza and SARS-CoV-2, affect dormant cancer cells in the lungs and lead to breast cancer metastasis. The lab investigates the connections between inflammation caused by these infections and the awakening of dormant cancer cells that can result in serious health complications. Their work aims to uncover mechanisms to prevent cancer recurrence and develop strategies for early detection and risk mitigation in cancer survivors.
Tatiana G Kutateladze — Dr. Tatiana G Kutateladze's lab studies how certain chemical changes in the molecular structure of DNA and proteins, known as epigenetic modifications, influence aging and diseases like Alzheimer's. Their research focuses on a specific modification on histones, the proteins that package DNA, and how this impacts gene expression and cellular function. By understanding these processes, the lab aims to find new ways to prevent or treat age-related disorders.
Manisha N Patel — Dr. Manisha N Patel's lab at the University Of Colorado Denver focuses on understanding how mitochondria, the energy powerhouses of cells, contribute to neuroinflammation and astrogliosis in epilepsy. By investigating the role of mitochondrial reactive oxygen species (mtROS) in neuronal-glial communication, the lab aims to identify potential new therapies for treating epilepsy. The research combines various techniques to explore how oxidative stress impacts brain function and inflammation in seizure models.
Heide L. Ford — Dr. Heide L. Ford's lab focuses on understanding the mechanisms behind aggressive pediatric cancers like Rhabdomyosarcoma (RMS) and Triple Negative Breast Cancer (TNBC). Their research aims to uncover how specific transcription factors influence tumor growth and differentiation, potentially leading to targeted therapies that minimize toxicity. By combining advanced genetic tools and animal models, the team seeks to develop better treatments for these challenging cancers.
Mark L Dell'Acqua — Dr. Mark L Dell'Acqua's lab at the University of Colorado Denver focuses on understanding how amyloid beta, a protein involved in Alzheimer's disease, disrupts synaptic function in the brain. The lab investigates the molecular signaling pathways that control synaptic plasticity—the brain's ability to adapt and change. By studying these pathways, the research aims to identify potential therapeutic targets that could help preserve cognitive function in individuals affected by Alzheimer's disease.
Thomas Anchordoquy — Dr. Thomas Anchordoquy's research lab at the University of Colorado Denver focuses on improving cancer chemotherapy by developing strategies to minimize the off-target accumulation of drug-containing nanoparticles in healthy tissues. This innovative approach leverages the immune response to enhance drug delivery specifically to tumors while reducing adverse effects. The lab's work is essential in finding ways to make cancer treatments more effective and less toxic for patients.
Dmitri Simberg — Dr. Dmitri Simberg's lab focuses on developing innovative drug delivery systems using lipid nanoparticles for treating invasive glioblastoma, a highly aggressive brain tumor. The research aims to enhance the effectiveness of drug therapies by overcoming barriers in the brain and targeting tumor cells directly. By understanding the trafficking and formulation of lipid-based nanoparticles, the lab seeks to improve treatment outcomes for patients with this challenging disease.
Matthew J Kennedy — Dr. Matthew J. Kennedy's lab at the University of Colorado Denver focuses on understanding how the tiny structures within synapses, which are connections between neurons, influence brain function. They are developing innovative tools to manipulate these structures in real time, which will help reveal their role in important cognitive processes, such as learning and memory. This research aims to bridge the gap between the molecular dynamics of synapses and their impact on cognitive functions, potentially shedding light on brain disorders linked to synaptic dysfunction.