University of Colorado Denver/Anschutz Medical Campus · Pharmacology

Mitochondrial Neuroinflammation Lab

Manisha N Patel · Denver, Colorado

Research Focus

Dr. Manisha N Patel's lab at the University Of Colorado Denver focuses on understanding how mitochondria, the energy powerhouses of cells, contribute to neuroinflammation and astrogliosis in epilepsy. By investigating the role of mitochondrial reactive oxygen species (mtROS) in neuronal-glial communication, the lab aims to identify potential new therapies for treating epilepsy. The research combines various techniques to explore how oxidative stress impacts brain function and inflammation in seizure models.

neuroinflammationastrogliosismitochondriaepilepsyreactive oxygen speciesoxidative stressglial fibrillary acidic proteinmetabolism-based therapiesmouse modelsneural communications

Research Aims

AIM 01Investigate if mitochondrial oxidative stress increases astrogliosis in vitro.

AIM 02Assess the impact of neuronal mtROS on GFAP upregulation and astrogliosis in vivo.

AIM 03Evaluate the relationship between mtROS, astrogliosis, and cognitive dysfunction in epilepsy models.

Skills the Lab Values

2-photon imagingmouse modelsin vitro assaysmass spectrometrycell cultureprotein expression analysisfluorescence microscopyoxidative stress measurementmRNA expression techniquesneurochemical assays

Output against the department

Publications186top 47% of dept.219th of 462

this lab

most publishedleast published

Citations12ktop 34% of dept.155th of 462

this lab

most citedleast cited

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