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Jie Wu — Jie Wu's lab at the University of Oklahoma focuses on developing new drugs that target the RET oncogene in cancers such as lung and thyroid cancer. The lab aims to create next-generation RET inhibitors that can effectively treat patients who have developed resistance to existing therapies. By optimizing novel compounds, they work towards providing better therapeutic options for patients with RET-positive tumors.
Rajagopal Ramesh — Dr. Rajagopal Ramesh's lab focuses on innovative cancer treatments using advanced drug delivery systems and immune modulation techniques. They explore how exosomes, small vesicles released by cells, can carry cancer medications directly to tumors to improve treatment effectiveness and reduce side effects. The lab's research also investigates ways to combine these treatments with immune checkpoint inhibitors to enhance the body’s immune response against lung cancer.
Tiangang Li — Dr. Tiangang Li's research lab focuses on understanding how bile acids affect liver and gut health, particularly in the context of metabolic diseases. They are exploring a novel bile acid derivative, Gly--MCA, which may help alleviate bile acid toxicity and improve liver function in diseases characterized by bile duct injury. The lab is investigating how Gly--MCA works and its potential as a new treatment for conditions like primary biliary cholangitis and primary sclerosing cholangitis.
Leonidas Tsiokas — Dr. Leonidas Tsiokas's lab focuses on understanding how mutations in specific genes affect kidney function, specifically in conditions like Autosomal Dominant Polycystic Kidney Disease (ADPKD). His team seeks to uncover the role of the Polycystin complex—a group of proteins involved in kidney cyst formation—by exploring its function as a type of receptor that interacts with signaling molecules. Their research could lead to new treatments for kidney diseases.
Maureen Cox — Dr. Maureen Cox's lab is focused on understanding the relationship between the nervous and immune systems, particularly how adrenergic nerves influence immune memory and responses during infections. By studying how these nerves interact with T cells and stromal cells in lymph nodes, the lab aims to uncover mechanisms that can improve vaccine design and immune treatment strategies for patients with peripheral nerve damage. This research holds potential significance in enhancing the immune responses for individuals who are particularly vulnerable to infections.
Karen R Jonscher — Dr. Karen R Jonscher's lab focuses on understanding how maternal obesity affects the health of offspring, particularly in relation to nonalcoholic fatty liver disease (NAFLD). Her research uses a unique model of olive baboons to study the impact of maternal diet and supplements, such as pyrroloquinoline quinone (PQQ), on fetal development and metabolic health. The goal is to find safe dietary strategies to prevent metabolic diseases that can occur in children born to obese mothers.
Mark L Lang — Dr. Mark Lang's research lab focuses on developing better vaccines for Clostridioides difficile (C. difficile), a bacteria that causes significant health issues due to infection. The lab aims to create a more effective second-generation vaccine and understand how the toxins produced by C. difficile undermine the body's immune response. By studying these mechanisms, the team seeks to reduce the incidence of recurrent infections and improve public health outcomes related to C. difficile infections.