UOHUniversity of Oklahoma-Health Sciences Center · Physiology
Li Bile Lab
Tiangang Li · Oklahoma City, Oklahoma
Research Focus
Dr. Tiangang Li's research lab focuses on understanding how bile acids affect liver and gut health, particularly in the context of metabolic diseases. They are exploring a novel bile acid derivative, Gly--MCA, which may help alleviate bile acid toxicity and improve liver function in diseases characterized by bile duct injury. The lab is investigating how Gly--MCA works and its potential as a new treatment for conditions like primary biliary cholangitis and primary sclerosing cholangitis.
bile acidsmetabolic diseasescholestasisliver functiongut healthbile acid therapyGly--MCAFXR antagonisthepatobiliary disordersmicrobiome-dependent circulation
Research Aims
5AIM 01Investigate the efficacy of Gly--MCA in reducing bile acid toxicity.
AIM 02Characterize the mechanisms by which Gly--MCA affects bile acid metabolism.
AIM 03Compare the effects of Gly--MCA with current treatments like UDCA.
AIM 04Explore combinations of Gly--MCA with other therapeutic agents for enhanced effects.
AIM 05Determine how Gly--MCA modulates gut barrier function in cholestasis.
Skills the Lab Values
animal modelinggas chromatographymass spectrometryPCRcell culturebiochemical assaysmouse surgeriestissue histologyWestern blot techniquesimmunohistochemistry
Output against the department
Publications132bottom 43% of dept.163rd of 286
this lab
most publishedleast published
Citations11ktop 30% of dept.85th of 286
this lab
most citedleast cited
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