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Kai Xu — Dr. Kai Xu's lab at Ohio State University focuses on understanding henipaviruses, which can be deadly and have potential for future pandemics. The research aims to study the surface proteins of these viruses to develop better vaccines and treatments. This work is vital as henipaviruses can transfer between animals and humans, leading to serious outbreaks.
Jianrong Li — Dr. Jianrong Li's research lab focuses on developing innovative vaccines for gastrointestinal and respiratory viruses. One major project aims to create mucosal vaccines for norovirus, targeting a global health issue where no effective vaccines currently exist. Another project investigates RNA modifications in SARS-CoV-2, which could lead to improved treatments and vaccines against COVID-19. The lab combines advanced viral vector technology with cutting-edge genetic research to address critical public health challenges.
Glen N. Barber — Dr. Glen N. Barber's lab at Ohio State University studies how a protein called STING plays a key role in the immune system, particularly regarding how our bodies respond to infections and cancer. They focus on understanding the mechanisms by which STING signaling can make infected or damaged cells more recognizable to the immune system, potentially improving cancer treatment strategies. The lab's work has implications for developing more effective therapies for various health issues, including cancer and inflammatory diseases.
Xuefeng Liu — Dr. Xuefeng Liu's lab focuses on understanding prostate and bladder cancer, particularly the differences between African-American and European-American men. They develop innovative human cell models to study cancer progression and create non-invasive methods for monitoring bladder cancer. Their research aims to improve cancer detection and treatment outcomes by exploring the biological basis of cancer disparities and enhancing cancer cell culture techniques.
Jing Zhao — Dr. Jing Zhao's lab at Ohio State University is focused on understanding how certain proteins regulate the immune response during severe bacterial infections. They study the role of a specialized protein complex called the immunoproteasome, particularly how it contributes to inflammation and tissue damage in conditions like pneumonia and sepsis. The goal is to identify new targets for therapies that can help control harmful inflammation and improve patient outcomes.
Anil V Parwani — Dr. Anil V Parwani's lab at Ohio State University focuses on cancer research through the collection and management of human biospecimens. They work as part of a cooperative network that provides high-quality biological samples to researchers, enabling groundbreaking studies in cancer treatment and personalized medicine. Their work supports a better understanding of cancer biology and helps develop new therapies based on human tissues and clinical data.
Nuo Sun — Dr. Nuo Sun's lab focuses on understanding how mitochondrial health affects heart function as we age. They study processes called mitophagy and neddylation to see how the heart can maintain good mitochondrial quality and how these processes can be targeted for new treatments for heart diseases, particularly in regard to aging and metabolic changes. By using innovative mouse models and advanced genetic techniques, the lab aims to discover new insights into heart health and dysfunction.
Ming-Chen Hsu — Dr. Ming-Chen Hsu’s lab at Iowa State University focuses on improving heart valve disease treatments through advanced computer modeling and machine learning. They develop a digital twin technology that simulates how heart valves work to help doctors personalize interventions for patients. The goal is to enhance treatment effectiveness, make healthcare more efficient, and improve patients' quality of life.
Rizwan Ahmad — Dr. Rizwan Ahmad's lab at Ohio State University focuses on advancing cardiac imaging techniques to improve the diagnosis and treatment of heart valve diseases, particularly mitral valve regurgitation. The team is developing a new MRI protocol that enhances the speed and accuracy of blood flow measurements within the heart, aiming to enable better clinical decisions for patients with heart conditions. This research has the potential to significantly improve patient outcomes by providing more precise assessments compared to current methods.