Iowa State University · PhysiologyImmunoproteasome Research Lab
Jing Zhao · Ames, Iowa
Research Focus
Dr. Jing Zhao's lab at Ohio State University is focused on understanding how certain proteins regulate the immune response during severe bacterial infections. They study the role of a specialized protein complex called the immunoproteasome, particularly how it contributes to inflammation and tissue damage in conditions like pneumonia and sepsis. The goal is to identify new targets for therapies that can help control harmful inflammation and improve patient outcomes.
immunoproteasomeinflammationacute respiratory distress syndromebacterial infectionstherapeuticsprotein degradationsepsisgram-negative bacteriaUSP14
Research Aims
4AIM 01Investigate how the deubiquitinase USP14 regulates the assembly of the immunoproteasome.
AIM 02Examine the role of protein kinase C in influencing immunoproteasome assembly during inflammation.
AIM 03Identify the molecular mechanisms behind pro-inflammatory responses in bacterial pneumonia.
AIM 04Explore potential therapeutic strategies to inhibit the immunoproteasome and reduce lung injury.
Skills the Lab Values
molecular biology techniquesanimal modelscell cultureprotein analysisphosphorylation assaysRNA extractionWestern blottingimmunofluorescence microscopydata analysis using Python
Output against the department
Publications143bottom 47% of dept.150th of 286
this lab
most publishedleast published
Citations27ktop 9% of dept.25th of 286
this lab
most citedleast cited
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