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Ali Shilatifard — Dr. Ali Shilatifard's lab focuses on understanding how mutations in chromatin modifiers like MLL4 contribute to cancer, especially bladder cancer. His research combines biochemical studies with pre-clinical trials to explore how these mutations can inform targeted therapies and improve patient treatment options. By studying specific mutations and their effects, the lab aims to develop biomarkers for better cancer diagnostics and treatment strategies.
Dalton James Surmeier — Dr. Dalton Surmeier's lab at Northwestern University focuses on understanding the mechanisms underlying Parkinson's disease (PD) and developing new therapeutic strategies. The research aims to dissect the roles of specific neurons in the brain that are involved in the disease, particularly how they relate to motor symptoms and side effects of standard treatments. By employing advanced genetic tools and rodent models, the lab seeks to uncover insights that could lead to improved therapies for PD patients.
Kristen Knutson — Dr. Kristen Knutson's lab focuses on understanding the connection between sleep and Alzheimer's disease by studying how specific proteins in the blood are influenced by sleep patterns. The research aims to identify biomarkers that can predict cognitive performance and dementia risk, providing insights that could lead to better prevention strategies. Ultimately, their work seeks to connect sleep health with brain function, especially in older adults.
Marek-Marsel M Mesulam — Dr. Marek-Marsel Mesulam's lab focuses on understanding Primary Progressive Aphasia (PPA), a type of dementia that primarily affects language abilities while preserving memory. The lab studies the distinct patterns of brain degeneration in PPA, particularly in the left hemisphere, and aims to link these patterns to the underlying diseases such as Alzheimer's and frontotemporal degeneration. By examining biological samples from patients, the lab is exploring how to personalize treatment options based on individual differences in brain structure and function.
Shana O Kelley — Shana O'Kelley's lab focuses on developing advanced sensor technologies to continuously monitor heart failure biomarkers in patients. The lab's innovative research aims to create wearable sensors that can detect important biochemical signals without the need for complex reagents, making it easier to track heart health in real-time. By integrating electrochemical sensors with biocompatible materials, the team seeks to provide better management for heart failure patients through continuous monitoring.
Alfred L. George — Dr. Alfred L. George's lab at Northwestern University studies genetic causes of epilepsy, particularly focusing on disorders linked to the KCNQ2 gene. They aim to understand how mutations in this gene affect brain function and lead to different severity levels in epilepsy symptoms. The lab utilizes advanced technologies, including human stem cell models and genetically engineered mice, to explore these mechanisms, ultimately seeking to inform new treatments for affected patients.
Robert J Vassar — Dr. Robert J. Vassar's lab at Northwestern University focuses on understanding the mechanisms behind Alzheimer's disease (AD), particularly how specific proteins contribute to neuron degeneration and tau pathology. The lab investigates the roles of angiotensin converting enzyme (ACE1) and the protein annexin A6 in neuronal health and disease. Through their studies, they aim to discover new therapeutic strategies for AD by exploring the fundamental biological processes that lead to memory loss and cognitive decline.
Gordon M Shepherd — Dr. Gordon Shepherd's lab focuses on understanding how the brain controls movements, particularly through the study of the motor cortex circuits involved in arm and hand movements. The lab explores how different areas of the brain communicate during these actions, aiming to uncover mechanisms that may lead to better treatments for movement disorders. By using advanced techniques, the research seeks to advance our knowledge about how sensory information and motor planning interact in the brain.
Phyllis C. Zee — Dr. Phyllis C. Zee's lab focuses on understanding sleep disorders, especially Delayed Sleep-Wake Phase Disorder (DSWPD) and insomnia in older adults. The lab investigates the physiological and behavioral factors that influence sleep quality and cognitive function. By examining different phenotypes of sleep disorders and their underlying mechanisms, the research aims to develop personalized treatment strategies to improve sleep and overall health in affected individuals.