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Anthony Wayne Orr — Dr. Anthony Wayne Orr's lab at Louisiana State University Health Sciences Center in Shreveport focuses on understanding and treating atherosclerosis, a major cause of cardiovascular disease. The lab investigates how cells interact with the extracellular matrix and how specific proteins influence inflammation and plaque stability. By exploring novel therapeutic strategies, the lab aims to develop targeted treatments that can both reduce dangerous inflammation and stabilize plaque in patients with cardiovascular disease.
Arif Yurdagul — Dr. Arif Yurdagul's lab focuses on understanding the mechanisms behind atherosclerosis, particularly how inflammation and cell metabolism contribute to heart disease. Their research explores the role of specific cellular pathways that affect vascular remodeling and the stability of arterial plaques. By investigating the function of nutrient sensors in macrophages and polyamine metabolism in vascular smooth muscle cells, they aim to identify new therapeutic strategies to mitigate atherosclerosis and improve cardiovascular health.
Md. Shenuarin Bhuiyan — Dr. Md. Shenuarin Bhuiyan's lab at Louisiana State University focuses on understanding how a specific protein, Sigma 1 receptor, helps protect the heart under stress by regulating cell cleaning processes called macro-autophagy and mitophagy. The lab investigates the role of this receptor in heart failure to uncover new ways to treat the condition. Using genetically modified mice and advanced biochemical techniques, the lab aims to provide insights into the mechanisms that could lead to new therapies for heart diseases.
Quanguang Zhang — Dr. Quanguang Zhang's lab focuses on understanding the effects of silent brain ischemia on Alzheimer’s dementia. They investigate how conditions like cardiac arrest and stroke, which often leave patients asymptomatic, can lead to long-term cognitive decline. The lab is exploring innovative treatments, such as pulsed laser therapy, to protect the brain and prevent Alzheimer’s disease in models that mimic these conditions. The goal is to uncover the biological mechanisms linking silent brain ischemia to Alzheimer’s, offering potential new therapies for at-risk patients.
Hongyan Guo — Dr. Hongyan Guo's lab focuses on understanding how the herpes simplex virus type 1 (HSV-1) manipulates host cell death processes to spread during infection. They study a specific protein called ZBP1, which is involved in the programmed cell death pathway that helps control viral infections. By uncovering the mechanisms behind ZBP1's actions and its interaction with viral components, the lab aims to reveal new insights that could lead to better therapies against HSV-1 and similar viruses.
Oren Rom — Dr. Oren Rom's lab focuses on understanding the role of macrophages in cardiovascular diseases, particularly how their metabolism affects plaque stability in atherosclerosis. The research aims to uncover mechanisms behind macrophage behavior, specifically their ability to clear dead cells (efferocytosis) in arterial plaques. By restoring certain metabolic pathways, the lab hopes to find new therapeutic strategies to prevent harmful plaque ruptures and improve cardiovascular health.