University of North Texas Health Science Center · GeneticsJin Lab
Lingtao Jin · Fort Worth, Texas
Research Focus
Dr. Lingtao Jin's lab focuses on developing new therapeutic strategies for hard-to-treat cancers, particularly ovarian cancer and non-small cell lung cancer (NSCLC). The lab investigates how specific proteins influence cancer cell survival and drug resistance, aiming to create more effective treatments through innovative approaches like PROTACs and targeting glycosylation pathways. Their research could lead to improved responses to existing cancer therapies.
ovarian cancerlung cancerdrug resistancePROTACglycosylationEGFRcancer therapykinasesurvival signalingHER3
Research Aims
5AIM 01Investigate the role of AAK1 in mediating paclitaxel resistance in ovarian cancer.
AIM 02Develop PROTACs to selectively degrade AAK1 and enhance paclitaxel efficacy.
AIM 03Understand how GALNT3 influences HER3 signaling in EGFR mutant NSCLC.
AIM 04Test the effectiveness of targeting GALNT3 in combination with EGFR inhibitors.
AIM 05Explore the mechanisms of O-linked glycosylation in cancer signaling pathways.
Skills the Lab Values
cell culturein vivo modelsshRNA screeningmolecular cloningWestern blottingimmunofluorescenceRNA sequencingdrug developmentbioinformaticspharmacology
Output against the department
Publications72bottom 19% of dept.211th of 259
this lab
most publishedleast published
Citations2.3kbottom 9% of dept.235th of 259
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.