University of North Carolina at Chapel Hill · Microbiology & ImmunologyHIV Reservoir Dynamics Lab
Sarah Beth Joseph · Chapel Hill, North Carolina
Research Focus
Dr. Sarah Beth Joseph's lab focuses on understanding how certain HIV-infected cells manage to survive in the body despite the immune system's efforts to eliminate them. By examining the differences between 'early' and 'late' infection reservoir cells, they aim to discover why some cells resist clearance and how to enhance the immune response against them. Their work could lead to better strategies for curing HIV infections through improved identification and targeting of these resilient cells.
HIVimmunologycell clearanceantigen presentationproviral geneticsepigeneticsT cell responsesreservoir cellsimmune evasion
Research Aims
5AIM 01Identify features of early and late proviruses in HIV-infected individuals
AIM 02Examine T cell stimulation sensitivity of 'early' and 'late' HIV reservoir cells
AIM 03Investigate genetic and epigenetic factors affecting HIV cell clearance
AIM 04Improve antigen presentation in HIV-infected cells
AIM 05Assess effectiveness of enhanced antigen presentation on killing HIV-infected cells.
Skills the Lab Values
PCRcell cultureflow cytometryT cell isolationgenetic sequencingepigenetic analysisimmunoassaysdata analysis in Ranimal modelsbiostatistics
Output against the department
Publications162top 41% of dept.201st of 486
this lab
most publishedleast published
Citations5.9kbottom 43% of dept.275th of 486
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.