Oregon Health & Science University · NeuroscienceGouaux Lab
James E Gouaux · Portland, Oregon
Research Focus
Dr. James E. Gouaux's lab at Oregon Health & Science University focuses on understanding how nerve cells communicate through neurotransmitters. They study the 3D structures of receptors and transporters that play crucial roles in transmitting signals in the brain, revealing how these proteins function and interact with drugs. This research not only contributes to our knowledge of brain function but also has implications for treating neurological disorders.
neurotransmittersligand-gated ion channelsneurotransmitter transportersreceptor structurecryo-electron microscopy
Research Aims
5AIM 01Isolate native receptor complexes from brain tissue to study their structure and function.
AIM 02Characterize the mechanisms by which neurotransmitter transporters operate.
AIM 03Investigate how small molecules interact with neurotransmitter transporters.
AIM 04Map the localization of ion channels at synapses using advanced imaging techniques.
AIM 05Examine post-translational modifications of transporters and their effects.
Skills the Lab Values
cryogenic electron microscopyprotein purificationantibody designbiochemical assayscell cultureneuroscience techniquesimmunohistochemistryflow cytometrymolecular modeling
Output against the department
Publications1bottom 1% of dept.671st of 671
this lab
most publishedleast published
Citations0bottom 1% of dept.671st of 671
this lab
most citedleast cited
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