University of California-Santa Cruz · ChemistryCircadian Biology and Mechanisms Lab
Carrie L Partch · Santa Cruz, California
Research Focus
Carrie L. Partch's lab at UC Santa Cruz studies the molecular mechanisms behind circadian rhythms, the biological processes that synchronize our internal clocks with the 24-hour solar cycle. By examining clock proteins from various organisms, including cyanobacteria and humans, the lab aims to uncover how these proteins interact and adapt to environmental cues, potentially informing the development of new therapies to enhance human health.
circadian rhythmsbiochemical mechanismsclock proteinsstructural biologypost-translational modifications
Research Aims
5AIM 01Determine the biochemical principles underlying circadian signaling.
AIM 02Investigate the structural basis of protein assemblies from diverse biological clocks.
AIM 03Study the effects of post-translational modifications on clock protein functions.
AIM 04Explore the mechanisms for clock entrainment to external signals.
AIM 05Identify potential pharmacological interventions for circadian rhythm disorders.
Skills the Lab Values
biochemistrycell cultureprotein purificationstructural biology techniquessize-exclusion chromatographycircular dichroism spectroscopy
Output against the department
Publications147bottom 36% of dept.139th of 216
this lab
most publishedleast published
Citations6.6kbottom 42% of dept.126th of 216
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.