University of Oregon · ChemistryNolen Actin Lab
Bradley J Nolen · Eugene, Oregon
Research Focus
Dr. Bradley J. Nolen's lab at the University of Oregon studies actin filaments, which are essential components of cells. They focus on how certain proteins regulate the assembly and architecture of actin networks, which play important roles in processes like bacterial infections and cancer metastasis. By exploring the mechanisms of these proteins, the lab aims to uncover insights that could lead to new treatments for diseases that manipulate these cellular processes.
actin filamentsArp2/3 complexcell motilitycancer metastasisbacterial infectionbiochemical reconstitutionlive cell imaging
Research Aims
5AIM 01Investigate how WASP proteins activate the Arp2/3 complex.
AIM 02Determine the role of coronin 7 in actin network remodeling.
AIM 03Explore the interplay between WASP and WDS proteins in actin assembly.
AIM 04Assess the molecular mechanisms of actin debranching.
AIM 05Elucidate how actin network architecture affects cellular processes.
Skills the Lab Values
biochemical assayssingle molecule fluorescenceelectron microscopylive cell imagingmolecular dynamics simulationsprotein purificationfilament-level modelingactin polymerization
Output against the department
Publications73bottom 14% of dept.186th of 216
this lab
most publishedleast published
Citations4.0kbottom 28% of dept.156th of 216
this lab
most citedleast cited
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