The University of Texas Medical Branch at Galveston · Microbiology & ImmunologyGarg Cardiomyopathy Lab
Nisha Jain Garg · Galveston, Texas
Research Focus
Dr. Nisha Jain Garg's lab focuses on understanding the molecular mechanisms behind Chagas disease, particularly how certain proteins affect heart function during the disease. By studying how the splicing of specific genes changes during infection, the lab aims to find new therapeutic strategies that could improve heart health in patients affected by Chagas. Their work bridges molecular biology and cardiology, aiming to offer insights into potential treatments for this serious condition.
Chagas Diseasecardiomyopathyalternative splicingPARP1RBFOX2mitochondrial functiongene expressionpolyadenylationcardiac health
Research Aims
3AIM 01Investigate how RBFOX2 isoforms change over time in Chagas disease.
AIM 02Determine if enhancing RBFOX2 and PARP1 balance can improve heart function during Trypanosoma cruzi infection.
AIM 03Explore the mechanisms by which PARP1 affects the polyadenylation and stability of mitochondrial mRNAs in Chagas disease.
Skills the Lab Values
cell cultureRNA sequencingPCRmouse modelsWestern blotflow cytometrymolecular cloninggene expression analysisbioinformatics
Output against the department
Publications289top 17% of dept.85th of 486
this lab
most publishedleast published
Citations6.6kbottom 48% of dept.255th of 486
this lab
most citedleast cited
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