Thomas Jefferson University · BiologyRigoutsos RNA Lab
Isidore Rigoutsos · Philadelphia, Pennsylvania
Research Focus
Dr. Isidore Rigoutsos' lab at Thomas Jefferson University focuses on understanding small RNA molecules, particularly variations of microRNAs, and fragments from tRNAs and rRNAs. They aim to develop specialized tools and databases that will help researchers accurately analyze and mine these RNA types from sequencing data. The lab’s work is crucial for improving our understanding of how these molecules regulate gene expression in different contexts, such as in human health and disease, particularly by investigating their roles in breast cancer metastasis.
microRNAsisomiRstRNA fragmentsrRNA fragmentsRNA sequencingmRNA regulationbreast cancerdata miningbioinformatics
Research Aims
4AIM 01Build specialized tools to accurately mine isomiRs, tRFs, and rRFs from RNA-seq data.
AIM 02Create databases to organize and present information about small RNAs already compiled from public datasets.
AIM 03Develop a system that auto-identifies and annotates newly added datasets related to small RNAs each month.
AIM 04Produce educational materials and systems to facilitate user interaction and feedback about these tools.
Skills the Lab Values
RNA sequencingbioinformaticsdatabase developmentdata analysisexperimental validationsoftware programminggene expression analysisstatistical modelingliterature review
Output against the department
Publications320top 17% of dept.173rd of 1,033
this lab
most publishedleast published
Citations26ktop 15% of dept.151st of 1,033
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.