University of California-San Diego · NeuroscienceCognition Care Lab
Douglas R Galasko · La Jolla, California
Research Focus
Dr. Douglas Galasko's lab focuses on research related to Alzheimer's disease, a chronic condition that affects memory and cognition. The lab is currently developing a new drug, GSM-779690, which aims to prevent and slow progress of the disease, particularly in individuals at high genetic risk. This research includes conducting various safety and toxicology studies before advancing to clinical trials.
Alzheimer's Diseasedrug developmentpharmacologyGSM-779690biomarkersneurodegenerationclinical trialssafety studiestoxicologyamyloid
Research Aims
5AIM 01Develop GSM-779690 as a potential preventive treatment for Alzheimer's disease.
AIM 02Evaluate the drug's safety through chronic toxicity studies in animal models.
AIM 03Conduct embryo-fetal development studies to assess reproductive toxicity.
AIM 04Prepare for phase 1 clinical trials to test safety in humans.
AIM 05Support the advancement to phase 2 clinical trials through comprehensive safety assessments.
Skills the Lab Values
cell culturein vitro pharmacologytoxicology studiesanimal modelsdrug safety evaluationinduction of disease modelsbiochemical assaysdata analysis of clinical trialsbehavioral testing of modelspharmacokinetics assessment
Output against the department
Publications561top 10% of dept.65th of 671
this lab
most publishedleast published
Citations86ktop 3% of dept.17th of 671
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.