University of Kentucky · BiochemistryTriple-Negative Breast Cancer Research Lab
Binhua P Zhou · Lexington, Kentucky
Research Focus
Dr. Binhua P Zhou's lab focuses on understanding and combating triple-negative breast cancer (TNBC), a highly aggressive form of cancer with poor prognosis. The research aims to investigate how a specific enzyme, nicotinamide N-methyltransferase (NNMT), helps TNBC cells survive under stress and contributes to their spread in the body. By targeting NNMT with specially designed inhibitors, the lab seeks to develop new treatment strategies to improve outcomes for patients with TNBC.
triple-negative breast cancermetabolic dysregulationferroptosisNicotinamide N-methyltransferasecancer therapypreclinical modelsdrug discoveryreactive oxygen species
Research Aims
3AIM 01Identify how NNMT contributes to anchorage-independent growth and ferroptosis resistance in TNBC cells.
AIM 02Evaluate the specificity and mechanisms of NNMT bisubstrate inhibitors in TNBC treatment.
AIM 03Explore the therapeutic potential of NNMT inhibitors in pre-clinical mouse models.
Skills the Lab Values
cell culturemouse modelsCRISPRWestern blotRNA sequencingin vitro assaysdrug efficacy testingbiochemical assaysmolecular cloning
Output against the department
Publications219top 36% of dept.145th of 402
this lab
most publishedleast published
Citations21ktop 19% of dept.76th of 402
this lab
most citedleast cited
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