University of Pittsburgh-Pittsburgh Campus · NeuroscienceMarmoset Memory Lab
Afonso C Silva · Pittsburgh, Pennsylvania
Research Focus
Dr. Afonso C Silva's lab at the University of Pittsburgh focuses on understanding Alzheimer's disease by creating and studying marmoset models. These small primates offer a unique opportunity to explore the biological mechanisms behind Alzheimer's, and the lab aims to discover how the disease develops from its earliest stages. Through advanced imaging and genetic techniques, the research aims to enhance knowledge about both early-onset and late-onset Alzheimer's, potentially leading to new treatments.
Alzheimer's Diseasemarmoset modelsgene editingneuroimagingdisease progressionbehavioral phenotypingmolecular assaysaging biologybiological signatures
Research Aims
3AIM 01Establish marmoset models of early-onset Alzheimer's disease to investigate cellular and molecular determinants.
AIM 02Enhance understanding of late-onset Alzheimer's disease using genetically-engineered marmosets.
AIM 03Characterize phenotypic features of Alzheimer's in marmosets for translational research.
Skills the Lab Values
gene editingin vivo neuroimagingmolecular assayscognitive phenotypingbehavioral assessmentsanimal carebioinformaticsdata analysisexperimental design
Output against the department
Publications286top 24% of dept.164th of 671
this lab
most publishedleast published
Citations13ktop 31% of dept.210th of 671
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.