UTMThe University of Texas MD Anderson Cancer Center · Microbiology & Immunology
Epigenetics and Gene Regulation Lab
Xiaodong Cheng · Houston, Texas
Research Focus
Dr. Xiaodong Cheng's lab focuses on understanding how modifications to DNA and histones can affect gene expression. By studying the molecular mechanisms behind these epigenetic changes, the lab aims to uncover how transcription factors interact with DNA and how these processes can influence health and disease. This research is particularly relevant for developing new therapeutic strategies targeting gene regulation.
epigeneticsDNA methylationtranscription factorsgene expressionchromatin structure
Research Aims
4AIM 01Investigate the role of 5-methylcytosine and its oxidative forms in gene regulation.
AIM 02Uncover the mechanisms governing DNA and histone methylation and demethylation.
AIM 03Explore how transcription factors interact with methylated DNA to influence gene expression.
AIM 04Analyze the impact of modified cytosines on genome stability.
Skills the Lab Values
PCRchromatin immunoprecipitationcell cultureWestern blotRNA sequencing