University of Pennsylvania · NeuroscienceTau Dynamics Lab
Jeffrey S Phillips · Philadelphia, Pennsylvania
Research Focus
Dr. Jeffrey S Phillips's lab at the University of Pennsylvania is focused on understanding Alzheimer's disease, particularly how tau proteins spread in the brain and impact different cognitive functions. By using advanced imaging techniques and postmortem validation, the lab aims to uncover how changes in white matter may be connected to the progression of tau pathology. This research will help inform better diagnostic methods and therapies for Alzheimer's disease and its various forms.
Alzheimer's diseasetau pathologywhite matterimaging techniquescognitive declinemicrovascular diseasepostmortem analysislongitudinal studiesmagnetic resonance imaging
Research Aims
3AIM 01Examine how changes in white matter correspond to tau spread in Alzheimer's disease.
AIM 02Assess the relationship between cerebrovascular changes and tau pathology over time.
AIM 03Validate imaging findings with postmortem tissue analysis to understand disease mechanisms.
Skills the Lab Values
3-Tesla MRI imaging7-Tesla MRI imagingdiffusion MRIpositron emission tomography (PET)histopathology analysisaxonal transport modelinglongitudinal data analysiscerebrovascular assessmentresearch methodology
Output against the department
Publications117bottom 41% of dept.397th of 671
this lab
most publishedleast published
Citations1.6kbottom 9% of dept.608th of 671
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.