University of California-San Diego · EngineeringCellular Senescence and Immune Function Lab
Lingyan Shi · La Jolla, California
Research Focus
Dr. Lingyan Shi's lab at UC San Diego focuses on understanding how cellular senescence, particularly in immune tissues like the thymus, influences aging and immune function. The lab develops innovative imaging techniques to study senescent cells and their metabolic activity, aiming to uncover how these processes affect overall health and the immune system. By researching the mechanisms behind aging in immune cells, the lab hopes to improve interventions for age-related immune decline and enhance healthspan.
cellular senescencethymic agingimmunosenescencemetabolic activitymultimodal imaging
Research Aims
4AIM 01Develop advanced imaging systems to profile senescent cells in tissues.
AIM 02Investigate the transcriptomic changes associated with cellular senescence.
AIM 03Examine how thymic aging impacts T-cell diversity and immune function.
AIM 04Explore the metabolic dynamics of senescent cells in lymphoid tissues.
Skills the Lab Values
Raman spectroscopysingle-cell imagingimmunofluorescencespatial transcriptomicsmouse model experimentation
Output against the department
Publications234top 39% of dept.108th of 278
this lab
most publishedleast published
Citations4.0kbottom 30% of dept.195th of 278
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.