University of Notre Dame · ChemistryCancer Therapeutics and Targeted Inhibitors Lab
Brian S J Blagg · Notre Dame, Indiana
Research Focus
Dr. Brian S. J. Blagg's lab at the University of Notre Dame is engaged in innovative cancer research focused on developing targeted therapies. The lab primarily investigates inhibitors of heat shock proteins and their potential to treat challenging cancers, particularly prostate cancer and glaucoma. By creating specific inhibitors that reduce side effects and enhance the effectiveness of existing treatments, the lab aims to improve outcomes for patients with these serious conditions.
Hsp90 inhibitorsprostate cancerglaucomaGRP 94immunotherapydrug developmentisoform-selective inhibitorsER stresstherapeuticscancer treatment
Research Aims
5AIM 01Develop isoform-selective Hsp90 inhibitors for cancer treatment.
AIM 02Optimize GRP 94 inhibitors for ocular conditions.
AIM 03Evaluate the mechanisms of action of new cancer therapeutics.
AIM 04Assess the efficacy of selective inhibitors in preclinical models.
AIM 05Investigate the synergy of Hsp90 inhibitors with immunotherapy.
Skills the Lab Values
drug designcell culturein vivo modelsWestern blotflow cytometryPCRproliferation assaysbiochemical assaysimmunohistochemistryanimal handling
Output against the department
Publications390top 28% of dept.60th of 216
this lab
most publishedleast published
Citations10ktop 46% of dept.99th of 216
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.