Pennsylvania State University-Main Campus · BiologyBordenstein Microbiology Lab
Seth R Bordenstein · University Park, Pennsylvania
Research Focus
Dr. Seth R. Bordenstein's lab studies the interactions between bacteria and their insect hosts, focusing on a specific bacterium called Wolbachia. They investigate how Wolbachia manipulates insect reproduction, particularly in mosquitoes, to control the spread of diseases like Zika and dengue. By examining the molecular mechanisms behind these interactions, the lab aims to enhance strategies for using Wolbachia as a tool in public health to reduce mosquito populations and disease transmission.
Wolbachiacytoplasmic incompatibilitymale killinggametogenesisembryogenesisepigeneticsDrosophilaAedes aegyptivector control
Research Aims
3AIM 01Investigate pre-fertilization chromatin changes in sperm due to Wolbachia infection.
AIM 02Characterize protamine types and their role in embryonic lethality.
AIM 03Understand maternal epigenetic changes during oogenesis related to male killing.
Skills the Lab Values
CUT&Tag chromatin profilinggene knockouttransgenic techniquesRNA interferencecell culturemicroscopyDNA sequencingprotein analysisbioinformatics
Output against the department
Publications192top 33% of dept.344th of 1,033
this lab
most publishedleast published
Citations18ktop 23% of dept.234th of 1,033
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.